IGF1 is produced by the liver. When growth hormone reaches the liver it stimulates IGF1 to be produced.
Low protein diet = low IGF-1.
What influences levels of growth hormone (GH) and IGF-1 in the circulation include:
- Genetic make-up
- Time of day
- Exercise status
- Stress levels
- Nutrition level
- Body mass index (BMI)
- Disease state
- Estrogen status and xenobiotic intake.
IGF-1 is a primary mediator of the effects of growth hormone (GH).
Growth hormone is made in the anterior pituitary gland.
Then it’s released into the blood stream, where it stimulates the liver to produce IGF-1.
IGF-1 stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body.
Especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell, and lungs.
In addition, IGF-1 can regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis.